Apatinib good supplier in China CAS NO.811803-05-1

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Min.Order: 1 Gram
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Product Details

Keywords

Apatinib good supplier
811803-05-1
Apatinib factory

Quick Details

ProName: Apatinib good supplier in China
CasNo: 811803-05-1
Molecular Formula: C24H23N5O
Appearance: solid
Application: API，Pharmaceutical intermediates
DeliveryTime: 1-2days after the payment
PackAge: 1g to 1kg or as your request
Port: Shanghai, Shenzhen
ProductionCapacity: 500 Kilogram/Month
Purity: 99%
Storage: 2℃-8℃
Transportation: DHL, UPS, FEDEX EMS or as your request
LimitNum: 1 Gram
Residue on Ignition: ≤0.01
Heavy Metal: ≤0.03
Valid Period: 3years

Superiority

We are a leading provider and manufacturer of pharmaceutical and chemical products. Mainly involves API, pharmaceutical intermediates, polypeptide, and natural extract etc。We are capable to supply you with any quantity of the mentioned products with fast and secure delivery to any of your desire address .and any part of world with good prices. . We export products to USA, Canada, Mexico, Brazil, United Kingdom, Japan, Russia, Germany, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark, Bosnia and Herzegovina ect.

We work hard for getting sustainable development, and making contributions to our society and health industry of human being. Upholding international QC idea, we follow customers’ demands closely, and strive to offer customers stable qualities and excellent service. Through improving comprehensive strength continuously, we are working hard for get sustainable development! We persist in the management policy of People Oriented, and devote ourselves to providing the best products and services. The quality is the future market, the goodwill is the invisible market, the satisfaction of the customers is the eternal market. To center around the customers, providing the first-class products and services. To be guided by the market, create the perfect production and supply system. We welcome all kinds of cooperation with the friends all over the world on the fundamental business principle of "equality, mutual benefit and friendly cooperation”.

Process Capability : After-sale Service : We guarantee good quality products. . 100% refunded if parcel is not delivered or poor quality.

Details

we could support you:

1. best quality products;

2. competitive price in china market,

3. safe and fast shipping;

4. professional technical support;

5. samples order is welcomed

6. HNMR and HPLC will be offered after the order.

We are insisting on the tenet of "quality first, customer top, speed supreme, excellent quality and reasonable price", we would like to cooperate with you!

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Apatinib

Mol Download Chemical properties

CAS:: 811803-05-1

MF:: C24H23N5O

MW:: 397.47232

Density: 1.27

Description

Apatinib (YN968D1) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 with an IC₅₀ of 1 nM. Apatinib (YN968D1) also potently suppresses the activities of Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. Apatinib (YN968D1) inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ^[1]^[2]^[3].

IC₅₀ & Target^[1]

VEGFR2

1 nM (IC₅₀)

In Vitro

Apatinib (YN968D1) slightly inhibits proliferation of HUVEC stimulated by 20% FBS (IC₅₀=23.4 μM), whereas Apatinib significantly inhibits proliferation stimulated by 20 ng/mL VEGF (IC₅₀=0.17 μM). The IC₅₀ values of Sunitinib are lower under the same conditions (7.4 μM and 0.034 μM, respectively). 1 μM Apatinib significantly inhibits the migration of HUVEC induced by FBS, but does not affect proliferation of HUVEC, indicating that the inhibitory effect of Apatinib on FBS-induced migration is not due to the suppression of proliferation. At a concentration of 1 μM, Sunitinib also inhibits the migration of HUVEC^[1].

In Vivo

The antitumor potential of Apatinib (YN968D1) is evaluated in six human tumor xenografts in immunodeficient mice. Once-daily oral administration of Apatinib produces a dose-dependent inhibition of tumor growth in all tumor models examined. Statistically significant growth inhibition is obtained with 50 mg/kg per day Apatinib in three of five tumor xenografts tested. Each tumor xenograft model is significantly growth inhibited by Apatinib at the dose of 100 kg/day. Similar tumor growth inhibition is observed (T/C%, 8% to 18%) in mice following treatment with Apatinib at the dose of 200 kg/day. Full growth inhibition profiles are shown for three of the xenografts. Compared with the control animals, no effect of Apatinib treatment on bodyweight is observed at any dose level, which suggested that Apatinib is well tolerated^[1].

Molecular Weight

493.58

Formula

C??H??N?O?S

CAS No.

1218779-75-9

SMILES

O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)CCCC4)C=C3.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage